European Journal of Cardiovascular Medicine

Background- Currently, spinal anaesthesia is the preferred mode of regional anaesthesia for gynaecological surgeries as it is easy to administer and economical. Hyperbaric bupivacaine is the most common local anaesthetic in use, but it has short duration of action that may require early analgesic intervention postoperatively. Many additives have been used to increase the duration of action of local anaesthetic and currently dexmedetomidine is being used in different doses. Methods- This prospective, Randomized, comparative, single blinded study was carried out in the Department of Anaesthesiology, MGM Medical Collegeand MY Hospital, Indore, after approval from institutional ethics committee 60 patient qualifying inclusion criteria were included and randomly allocated in twoequal groups  • Group D3(n=30) patients received 3µg dexmedetomidine in combination with hyperbaric Bupivacaine (0.5%) to total volume of 3.5ml through intrathecal route. • Group D5(n=30) patients received 5µg dexmedetomidine in combination with hyperbaric Bupivacaine (0.5%) to total volume of 3.5ml through intrathecal route. Results- The mean duration of analgesia was significantly longer in Group D5 (474.33 ± 24.73 minutes) as compared to Group D3 (389.67 ± 26.97) (p=0.001).The onset of sensory block and motor block was significantly early in Group D5 than Group D3 (P<0.05). The mean duration of motor block was significantly longer in Group D5 (335.33 ± 20.13 minutes) than Group D3 (286.00 ± 21.59) (P=0.001).Analgesic use and intraoperative complications were similar in both the groups. (p > 0.05). Conclusions- Based on the findings and observations from our study, It can be concluded that Dexmedetomidine in a dose of 5µg seems to be a better adjuvant to hyperbaric bupivacaine in comparison to dexmedetomidine 3µg in terms of duration of post-operative analgesia and early onset of sensory and motor block.96