European Journal of Cardiovascular Medicine

Background:This study aimed to compare the efficacy and safety of ibuprofen gargle with lignocaine gargle given 30 minutes before surgery in preventing postoperative sore throat (POST) after endotracheal intubation for 24 hours postoperatively.Methods: Eighty ASA I–II patients undergoing elective surgery under general anaesthesia were enrolled in this prospective, randomised, observational study. Patients were allocated into 40 subjects each: Group –L and Group - I; Group-L received lignocaine viscous 2 % solution at 5mg/kg, and Group-I received crushed tab Ibuprofen 400mg diluted in 20ml of water.  Patients were asked to gargle for thirty seconds, thirty minutes before shifting to the operation theatre. Results: There was no statistically significant difference in the occurrence or severity of POST between the two groups for up to 24 hours after the surgery.Conclusions: Preoperative gargling with ibuprofen solution effectively reduces the incidence and severity of POST compared to lignocaine gargle.