European Journal of Cardiovascular Medicine

Background: Cardiovascular disease (CVD) is a leading cause of morbidity and mortality. India suffers the highest loss in potentially productive years of life, due to deaths from CVD.There are various investigations that have been utilised for diagnosis and management of acute coronary syndrome such as troponin ,CK-MB and 2D echo.There are few expensive investigations such as NT pro BNP that have been used as the prognostic factor in acute coronary syndrome.There is thus need of an investigation that can be done in peripheral setting which can be done easily and and has good prognostic value in acute coronary syndrome.  Objective: To study of neutrophil to lymphocyte ratio in acute coronary syndrome and its correlation with outcome Methods: This cross-sectional observational study was conducted in tertiary care hospital in Central India. Patients who were admitted to tertiary care centre with a diagnosis of ACS fulfilling the inclusion criteria were included in the present study. The study was conducted from June 2020 to Nov 2022. Results: Among the patients with N/L≤4, 36.1% had Killip class 1, 36.1% had Killip class 2, 19.4% had Killip class 3 and 8.3% had Killip class 4. Among the patients with N/L>4, 11.1% had Killip class 1, 30.6% had Killip class 2, 29.2% had Killip class 3 and 29.2% had Killip class 4. There was statistically significant difference. The mean CK MB of the patients with N/L≤4 was 570.90±36.29 and the mean CK MB of the patients with N/L>4 was 177.42±107.76. There was statistically significant difference. The mean 2D ECHO EF of the patients with N/L≤4 was 44.16±6.39 and the mean 2D ECHO EF of the patients with N/L>4 was 34.58±5.45. There was statistically significant difference. Among the patients with N/L≤4, all of them survived (100.0%); among the patients with N/L>4 15.3% died and 84.7% survived. There was statistically significant difference. Conclusions: The results of this study revealed that NLR is the strong predictive marker of ACS, so the study recommends using NLR as a good prognostic indicator for predicting short-term MACE and death in ACS patients.