Background: Dextrocardia is an uncommon congenital heart condition which occurs due to aberrant positioning of the heart in the right hemithorax. In the current case report, we describe a 69-yearold male who experienced retrosternal chest discomfort that spread to his right shoulder was diagnosed with dextrocardia with situs inversus. Due to this condition, a diagnostic challenge was encountered. Lead reversal on an electrocardiogram (ECG) showed features of dextrocardia with myocardial infarction (MI). A chest x-ray and an echocardiography also confirmed the diagnosis. After receiving successful coronary intervention, the patient was eventually discharged from the hospital.