Introduction: The management of peritonitis presents significant challenges to healthcare professionals, given its high morbidity and mortality rates. Peritoneal lavage is a therapeutic technique used in the management of peritonitis, involving the irrigation of the abdominal cavity with a solution to remove inflammatory debris, pathogens, and toxins. Different liquids have been employed for lavage. This study compares the effectiveness of peritoneal lavage with saline and metronidazole in instances of peritonitis that have undergone surgery. By examining the outcomes associated with each lavage solution, valuable insights can be gained into the optimal approach for managing this potentially life-threatening condition.