European Journal of Cardiovascular Medicine

Background: Vitamin D deficiency is associated with increased risk of coronary artery disease (CAD). However, this association has been the subject of controversial results. Aim: This study was designed to assess the correlation between vitamin D deficiency and severity of CAD assessed with SYNTAX (synergy between percutaneous coronary intervention with taxus and cardiac surgery) score among south Indian population. Methods: Across-sectional, observational study was conducted at a tertiary care center in India between June 2021 and May 2022. A total of 180 stable patients suspected with CAD and having an indication to undergo coronary angiography were included in the study. Baseline demographic and clinical investigations were carried out among all the patients. Risk factors for CAD were recorded. Serum vitamin D level was measured. SYNTAX score was used as an indicator to determine the severity of CAD. Results: Mean age of the patients was 56.6±10.7 years with male predominance (67.2%). Based on the SYNTAX score, patients were categorized into two groups: (a) SYNTAX score <23 (n=122) and (b) SYNTAX Score ≥23 (n=58).Among all the risk factors, vitamin D level (p<0.001) and diabetes mellitus (p<0.001) were found to be statistically significant. A moderately negative correlation existed between vitamin D level and SYNTAX score (r=-0.323). Vitamin D was inversely correlated with the occurrence of CAD (Odds ratio: 0.919; p = 0.001). Conclusion: According to our findings, deficiency of vitamin D may have a crucial role in the occurrence of severe CAD.