Background: Chronic obstructive pulmonary disease (COPD) is a significant public health concern characterized by a rising global mortality rate. The association between obesity and heightened morbidity and mortality is widely recognized in the general population. However, in the context of chronic obstructive pulmonary disease (COPD), an intriguing phenomenon referred to as the "obesity paradox" has been observed. The assessment of nutritional status serves as a valuable prognostic indicator for individuals diagnosed with chronic obstructive pulmonary disease (COPD). Methods: A cross-sectional study was undertaken at a tertiary care hospital in Central India, involving a sample of 125 patients diagnosed with chronic obstructive pulmonary disease (COPD). The objective of the study was to evaluate the body mass index (BMI) of these patients using Quetelet's formula. The study participants were chosen through the utilization of a systematic random sampling technique. Results: The study findings revealed that the average body mass index (BMI) was recorded as 24.93±4.0. The health-related quality of life of individuals who are undernourished was found to be significantly impacted. A statistically significant association was observed among all the components of the St. George's Respiratory Questionnaire (SGRQ). Conclusions: The findings of the study revealed that individuals with malnourished chronic obstructive pulmonary disease (COPD) exhibited a notable decline in their health-related quality of life and experienced significant restrictions in their airflow capacity.