European Journal of Cardiovascular Medicine

Background: Pulmonary function tests fulfil a pivotal role in respiratory medicine. They are used to diagnose airways obstruction, assess its severity and prognosis, delineate risk factors, detect early lung disease, and monitor for normal lung growth and lung function decline. Also many prediction equations are based on small numbers of subjects, using data collected decades ago so that changes in Spiro metric methodology and secular trends may affect the applicability to present day measurements. Materials and methods: This is a prospective study conducted for 6 months taking subjects. Total 90 subjects of age group 14 to 19 years were included in the study. A simple random sampling method was used to include subject for the study. Total number of subjects studied in each group was decided depending on the total population of the group in the locality. Data was collected from all willing volunteer subjects. However, the result obtained from the subjects coming under the exclusion criteria is excluded from the final calculation. Lung function parameters including FVC, FEV1 and FEV1/FVC were mainly used in our study. Result: Anthropometric and spirometry data for the 90 subjects who participated in spirometry testing is displayed. The mean Body mass index (BMI) for females was 24.2 and 25.2 for males. In females, the annual decrease in height was 0.19 cm/year (CI 0.13– 0.24, r2 = 0.27, F = 48.8, p < 0.001), whereas the annual decrease in males was 0.14 cm/year (CI 0.08–0.19, r2 = 0.15, F = 26.0, p < 0.001). Conclusion: Several CVD-linked proteins were associated with FEV1 and FVC but not with FEV1/FVC ratio, suggesting that the relationships are mainly with lung volume, not airflow obstruction. That increased levels of several proteins are associated with better lung function warrants further studies.