European Journal of Cardiovascular Medicine

Introduction: The central nervous system [CNS] is made up of the brain and the spinal cord. Cells within the CNS normally grow in an orderly and controlled way. If for some reason this disorder is disrupted the cells continue to divide and form a lump of tumour. CNS brain tumors is about equal in males and females – 51% for females and 49% for males (CBTRUS STUDY). The incidence of malignant CNS tumors is greater in males i.e. 7.2/1, 00,000. Brain tumor incidence tends to be higher in countries with more developed medical care. Aims: To evaluate the role of immunohistochemical markers in CNS tumours for confirmation and arriving at final diagnosis. Materials and Methods: In this prospective study of CNS neoplasms which covered 100 cases during January 2022 – January 2023, Darbhanga Medical College and Hospital, Bihar. The overall incidence of CNS neoplasms encountered by others was less than 9% (CBTRUS data) and in my observation it was 9.97%. Result: Of the 41 cases of the astrocytomas diagnosed there were 3 cases of grade I astrocytoma with an incidence of 7.3%. All the three cases, showed only an increase in cellularity. The three cases occurred in the middle age group with a slight increase in males (2:1). Conclusion: We conclude that, Primary CNS tumours are seen supratentorially in adults and in children it occurs infratentorially and Astrocytomas constitute the most common CNS tumor. Grading of astrocytomas by WHO norms reveal grade II pattern as the commonest.