European Journal of Cardiovascular Medicine

Introduction: Acute kidney injury is a common clinical condition encountered in our hospital. This study is an attempt to evaluate the clinical profile and to investigate the risk factors for poor prognosis among critically ill patients with acute kidney injury. Materials & Methods: A hospital-based cross-sectional study was conducted after ethics committee approval in an ICU of a tertiary care hospital. Study included 70 cases admitted in ICU during the study period, and also having acute kidney injury. Etiology for development of AKI was identified using appropriate investigations. Outcome was studied in the form of recovery, death, or discharge on dialysis. Data was analyzed by SPSS ver 26.0. Results: Mean age of the study cases was 46.58 years with 61.4% males. Intrinsic etiologies for development of AKI were seen in majority of the cases (71.4%) followed by pre-renal etiologies (27.1%).  Mortality was observed among 28.6% cases. On univariate analysis, elderly age (>60 years), high APACHE II Score and co-morbidities like cirrhosis, sepsis, ARDS and IHD were observed to be significantly associated with mortality among AKI cases. On multi-variate analysis, only APACHE II score was observed as significant predictor of mortality in ICU cases developing AKI. Conclusion: Acute kidney injury is a serious problem in critically ill cases with over one fourth of the ICU cases developing AKI succumbed to death. Advancing age, high APACHE II score and presence of associated co-morbidities were associated with poor prognosis.