European Journal of Cardiovascular Medicine

Introduction- Hypertensive disorders of pregnancy constitute one of the leading causes of maternal and perinatal mortality worldwide, specially in developing nations with poor access to health facilities. An easy, cost effective and precise diagnostic algorithm needs to be developed for early detection of preeclampsia in order to reduce maternal and fetral mortality. There are also marked changes in the coagulation and fibrinolytic system occurs during normal pregnancy leading to hypercoagulable state. These changes are more magnified during eclampsia and preeclampsia. Coagulation activation probably represents a secondary event consequent upon endothelial activation and damage. Antithrombin which binds and inactivates thrombin correlates inversely with the level of proteinuria and subsequent renal dysfunction. aim And Objectives-To evaluate platelet parameters in prediction of preeclampsia, assess platelet indices namely platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (PLCR) in women with preeclampsia compared with healthy controls. Determine correlation between platelet count and platelet indices in preeclampsia patients and normal pregnancy,and assess coagulation parameters and LFT levels in women with preeclampsia and normal pregnancy. Materials And Methods- It is a Prospective Case Control study included women with pre-eclampsia and control study group included healthy normotensive pregnant women of age group between 18-35 years of more than 20 weeks gestation. Total 102 cases taken [51 preeclampsia patients and 51 healthy pregnant women] Results- The platelet count in preeclampsia was significantly lower than in normotensive control group. while all platelet indices were increased with preeclampsia with a statistically significant difference p value-0.00. Results also showed an increase in coagulation parameters and liver function variables in preeclampsia patients when compared with the control group. Conclusion-Pregnancy induced hypertension is a significant cause of maternal and fetal morbidity and mortality. The current study was undertaken to study about the platelet parameters and coagulation profile in early detection and prediction of severity of preeclampsia. We have compared multiple laboratory variables in women with preeclampsia with normotensive patients.