European Journal of Cardiovascular Medicine

Background: Thyroid dysfunction is the second most prevalent medical disorder which has impact on reproductive health and pregnancy outcome. Because of the link of thyroid auto antibodies with various pregnancy related complications and antithyroid peroxidase antibody (TPO Ab) being most common of all of them, can be used as a surrogate marker for thyroid related adverse pregnancy outcomes. Hence, this present study is designed to further elucidate any association of TPO Ab and TSH levesl with adverse pregnancy outcomes. Aims: The present study was undertaken to determine pregnancy outcomes between TPO Ab positive and negative hypothyroid mothers. Methods: This hospital based observational study was conducted in the Department of Gynaecology and Obstetrics, Raiganj Government Medical College, Uttar Dinajpur, West Bengal, India. 305 hypothyroid pregnant women at 1st trimester were chosen randomly between 1st June 2021 to 31st May 2022. The data was tabulated in Microsoft Excel software and analysed with SPSSV.20 software. Results: Maximum participants belonged to age group 15-20 years i.e. 115 (37.7%), followed by 21-25 years’ age group, 92 (30.2%) Mean age of the participants was 23.30 years. Mothers with high TPO were 127 (41.6%). In our study 74 (24.3%) mothers required 25 mcg Levothyroxin followed by 12.5 mcg required for 58 (19%) mothers. GDM (27.78% vs 12.29%, p <0.001), were significantly higher in TPO Ab positive than TPO Ab negative hypothyroid mothers. Conclusions: Pregnant women with hypothyroidism and positive TPO Ab status were more predisposed to GDM than TPO Ab negative women.