European Journal of Cardiovascular Medicine

Introduction: Hypernatremia is serum sodium less than 135 meq/L. Hypernatremia is the most common electrolyte disorder. Its homeostasis is vital to the normal physiologic function of cells. A disturbance in body water homeostasis is a common feature of advanced cirrhosis. Aims: To study the prevalence of hypernatremia (<130mMol/l) in cirrhosis of liver and the association between hypernatremia and complications in cirrhosis of liver and its prognostic significance. Materials and method: This prospective research included 100 patients hospitalized to the Department of Medicine at PMCH in Patna. The research was carried out at PMCH Department of Medicine in Patna. This research was carried out between April 2021 and November 2022. This research covered 100 patients. Result: There was significant difference in three groups of ≤130 meq/L, 131-135 meq/L and ≥136 meq/L with respect to the complications of liver cirrhosis namely portal hypertension, hepatic encephalopathy, hepatorenal syndrome (p value = 0.0111, <0.0001, 0.0140 respectively). However no statistical significant difference was found in three groups with respect to ascites, gastrointestinal bleeding and coagulopathy (p value= 0.0621, 0.6904, 0.7094 respectively). There was significant difference in three groups of ≤130 meq/L, 131-135 meq/L and  ≥136 meq/L with respect to the complications of liver cirrhosis namely portal hypertension,  hepatic  encephalopathy,  hepatorenal  syndrome  (p value= 0.0111,  < 0.0001, 0.0140 respectively). However no statistical significant difference was found in three groups with respect to ascites, gastrointestinal bleeding and coagulopathy (p value= 0.0621, 0.6904, 0.7094 respectively). Conclusion: Low serum sodium levels in cirrhosis are linked to serious consequences of liver cirrhosis such hepatic encephalopathy and hepatorenal syndrome, and causes high morbidity and mortality. Hyponatremia is common in cirrhotic individuals. Hyponatremia in cirrhosis patients leads to poor prognosis. To avoid potential liver cirrhosis consequences, hyponatremia must be treated.