European Journal of Cardiovascular Medicine

Introduction: Myocardial infarction (MI), the end outcome of coronary artery disease (CAD), continues to be a major cause of mortality and morbidity worldwide. Over the past 50 years, it has been abundantly obvious that the series of thrombotic events that occur after an atherosclerotic plaque rupture obstructs the coronary artery, cutting off the oxygen and blood supply to the myocardial and leading to infarction. Aims: To assess the relationship between N-terminal pro- Brain natriuretic peptide levels on admission in ST elevation myocardial infarction (STEMI) and its short term complications, to determine the value of NT-pro-BNP in predicting short term outcome in patients with STEMI and compare the effectiveness of NT-pro BNP with cardiac troponin T and left ventricular ejection fraction in predicting the short term outcomes in STEMI. Materials and method: The present studywas a cross-sectional study. This study was conducted from April 2021 to November 2022in Patna Medical College and Hospital, Patna were included as cases. Total 40 patients were included in this study. Result: Out of the 40 patients studied, 45 % of the patients had ALWMI, 15 % had ASMI, 32. 5 % with IWMI and 7. 5% with IWMI+RWMI. 23 (57. 5%) were smokers. The relation between smoking and NT- pro BNP was not statistically significant. NT- pro BNP levels in the full cohort ranged from 246 to 3000 pg/ml. The mean levels were 1585. 65± 999 .133 pg/ml with the median NT- pro BNP as 1483 .50 pg/ml. There was a significantly higher incidence of arrhyhmias (p – 0.001), cardiac failure (p– 0.043), lower ejection fraction (p-< 0.020) and deaths (p-0.024) in the group who had above median NT- pro- BNP values. All 13 patients who had complications belonged to the above median NT pro BNP group. (p- <0.0001). The relation between the cardiac troponin T values, NT- pro BNP values, complications and deaths were not statistically significant. There was no statistical significance in the relation between LVEF < 50 % and the occurrence of complications, deaths. However there was strong correlation between LVEF < 50 % and NT- pro BNP above the median. (p – 0.020). Conclusion: NT-pro BNP is a superior short term prognostic indicator than cardiac troponin T and LVEF. It is a valuable tool for risk stratifying acute MI patients so that suitable treatment options may be developed and NT-pro BNP is a powerful predictor of short term prognosis in AMI, including mortality.