European Journal of Cardiovascular Medicine

Purpose: The purpose of the study was to evaluate the postoperative analgesia produced by low-dose Intrathecal Morphine as an adjuvant to 0.5% Hyperbaric Bupivacaine spinal anaesthesia and its side-effect profile in Lower Segment Cesarean patients. Methods: It was a prospective observational study conducted in 150 patients who underwent Cesarean section delivery under general anaesthesia. The duration of the study was one year, and it was conducted in a tertiary care hospital in the UAE. Result: This study included 150 participants. Postoperative VAS pain scores averaged 0.21 in the study population. Low-dose ITM provided postoperative analgesia for all 150 patients. The average 24-hour pruritus score was 0.01.   The study group's mean PONV grade was 1.01.  The first postoperative day was nausea-free for 88% of 132 participants. 149 patients (99.3%) had a respiratory rate exceeding 10/minute. The study population averaged 16.7 breaths per minute.  149 individuals (99.3%) had SpO2 above 92%. The study group averaged 98.1% SpO2. Our patients experienced no respiratory depression. The study group's average MAP was 81 mmHg, 100% of 150 patients had MAP values < 60 mmHg. Conclusion: The study concludes that the addition of 0.075 mg of Intrathecal Morphine is an excellent adjuvant to 12.5 mg of 0.5% Hyperbaric Bupivacaine spinal anaesthesia with the lowest side-effect profile in Lower Segment Cesarean patients for spinal anaesthesia and also recommends the use of I.V Ondansetron 8 mg immediately after spinal anaesthesia as an antiemetic prophylaxis to have a comparatively lower incidence of PONV postoperatively. This prophylactic ondansetron also tends to significantly reduce the frequency of hypotensive episodes which allowed us to use reduced doses of vasopressor infusions as well.