European Journal of Cardiovascular Medicine

Background: The impact of coronavirus disease 2019 (COVID-19) on maternal and newborn health is unclear. We aimed to evaluate the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy and adverse pregnancy outcomes. Material and Method: present study is a hospital-based observational study of Covid-19-positive pregnant women who gave birth in the dedicated Covid block of Gandhi Medical College Bhopal during the data collection period. After ethical clearance, patient records were evaluated and included in the study if they met the criteria. The research question, hypothesis, aims, and objectives guided the analysis. Descriptive analysis showed data distribution in terms of frequency and percentage. The novel coronavirus COVID-19, which originated in Wuhan, China, caused a global pandemic in December 2019. COVID-19 increases morbidity and mortality in immune-dysregulated pregnant women. Due to pandemic restrictions, prenatal examination have changed. We studied pregnant COVID-19-infected women. We examined maternal and neonatal outcomes linked to COVID-19 infection in pregnant women. Results: Our investigation revealed that 90 (42.8%) antenatal women admitted in our hospital from March to August 2020 and 120 (57.2 %) admitted during second wave January 2021-june 2022 (study period) were COVID-19 positive.The current investigation reveals that 42.4% of the study participants required ICU care during the initial wave of the COVID-19 pandemic, while 59% required the same during the subsequent wave and 4.4% in first wave 17.5% in second required mechanical ventilation.During 1st wave 4 maternal death were observed while in second wave 21 maternal death were observed. Only 3.5% of the new born tested positive and 28.9% were admitted in NICU. Conclusion-Pregnancy accelerated mild to moderate symptoms. As in the general population pregnant women also died more in the second COVID-19 pandemic. Pregnancy worsens moderate to severe illness requiring ICU care. These affected patients had more intrauterine foetaldeath, oligohydramnios, premature rupture of membranes, preterm delivery, intrauterine growth restriction, NICU admissions, and oxygen and mechanical ventilation needs. Our study suggests COVID-19 complicates medical or obstetric comorbidities. The neonate's risk of complications and NICU admission increases with severe mother symptoms or comorbidities.