European Journal of Cardiovascular Medicine

Introduction: Previous studies reported an association of diabetes mellitus (DM) with TB susceptibility. Many studies were retrospective, had weak diagnostic criteria for DM, and did not assess other comorbidities. This study is addressing these limitations with a longitudinal comparison of patients with TB who are classified as diabetic or normoglycemic according to World Health Organization criteria. We report interim findings after enrolling 159 of a planned 300 subjects. Aims: Materials and Methods: Results: We expect that the trends in DM and pre-DM prevalence will be confirmed when the planned accrual is achieved. The varied prevalence of other TB comorbidities (smoking, alcohol consumption, undernutrition, and vitamin D insufficiency) and metformin treatment may also have influenced TB severity and treatment response. This will be comprehensively analyzed when full cohort data are available. Conclusions: Earlier study results reveal a strikingly high prevalence of glycemic disorders in Indian patients with pulmonary TB and unexpected heterogeneity within the patient population with diabetes and TB. This glycemic control heterogeneity has implications for the TB-DM interaction and the interpretation of TB studies relying exclusively on HbA1c to define diabetic status.