European Journal of Cardiovascular Medicine

Background: Hyperuricaemia is defined as an elevation of the uric acid level in the blood to more than 0.38 mmol/l. This increased uric acid gets deposited in the form of monosodium urate crystals in joint tissue to form a micro trophi complex. An increased uric acid level is associated with increased gouty risk. Antigout drugs such as allopurinol, Colchicine, probenecid, and Benzbromarone. The main action of these drugs is to decrease uric acid levels and symptoms of gouty arthritis. The main aim of our study is to detect a suitable mono-drug therapy for the treatment of gouty arthritis.  Aim: To study the effect of allopurinol, probenecid, and Benzbromarone mono-drug therapy in gouty arthritis patients in tertiary care hospitals. Material and method: The present study was conducted on 150 gout patients. All the patients were equally divided into three groups; group -1, 50 patients were treated with allopurinol, group 2, 50 patients treated with probenecid, and group -3, 50 patients were treated with Benzbromarone. All these patients were monitored with symptoms and also tested with blood pressure, serum creatinine, blood urea, and blood uric acid.  Results: In our study majority of the patients were male followed by female (p 0.342). With the age group of 61 – 65 years in all the groups (groups – 1, 2 & 3) respectively. On the basic characteristics of the gouty patients, 45.33% were alcoholic abuse, 35.33% were smokers, 52.66% were hypertensive, 80.66% were diabetic patients, 17.33% were Hypertriglyceridaemia, 45.33% were obesity, 21.33% positive family history and 58.66 % chronic tophaceous gout respectively. Based on the location of gouty arthritis and symptoms toes and swelling was observed in the majority of patients in all group – 1, 2 & 3. Based on biochemical parameters after 3 months of treatment, no significance was observed in serum creatinine in groups -1, 2 & 3 (p. >0.05) On blood urea no significance was observed in group -1(p>0.05), and significance was observed in blood urea in group 2 & 3 (p<0.05). Based on uric acid levels significance (p< 0.05) was observed in all three groups (group – 1, 2 & 3) respectively.  Conclusion:  Benzbromarone followed by is the better drug of choice in lower urea and uric acid levels compared with Probenecid and allopurinol group