European Journal of Cardiovascular Medicine

Background and objectives: The accepted method for preventing surgical site infections during orthopedic surgery, including arthroplasty, is prophylactic systemic antibiotics. There is sufficient data to support its effectiveness in avoiding or decreasing surgical site infection. Controversial issues with this method include the timing of administration, the appropriate antibiotics to utilize, and the appropriate antibiotic duration. Methods: The study compared the effects of three intravenous doses of Ceftriaxone 1 g over three days (group 2 n = 65) vs three hours (group 1 n = 65), was conducted on patients who were scheduled for orthopaedic operations with a particular exclusion and was followed up for a year. Results: In groups 1 and 2, 65 patients each received antibiotics for one day and three days, respectively. There were 45 men and 15 women in group 2, compared to 40 men and 20 women in group 1. The patients' ages ranged from five to seventy. The patients in groups 1 and 2 were, on average, 32.5 and 36 years old, respectively. Both groups reported regional edema, redness, and soreness at the surgical site for the first 48 hours after the procedure. These side effects eventually disappeared on their own. Both groups exhibited no signs of localized inflammation, infection, or pus production at a subsequent check-up.  Conclusion: In neither group did any of the cases experience any infection. The study is a step in developing policies about the use of antibiotics in our nation and shows the value of antibiotic prophylaxis.