Introduction: Hospital waste is “Any waste which is generated in the diagnosis, treatment or immunization of human beings or animals or in research” in a hospital. “Hospital waste is a special type of waste produced in small quantities carrying a high potential of infection and injury and high potential to transmit infection to others. There are serious health effects from public health standpoint if hospital waste is not handled properly. Usually, the terms medical waste, hospital waste, infectious, and regulated medical wastes are often used interchangeably with medical wastes since there is no universally accepted definition for these terms. Material and Methods: This is a Facility based cross-sectional study conducted at Health care facilities at various levels in Ganjam district. In each health care facility, the medical officer, the pharmacist, the staff nurse and attendant comprised our study population. Those health care providers who gave consent to participate in the study. Using the observation checklist, the facilities were observed for infrastructure, logistics and practice of the stake holders. Then, the respondents were interviewed using the structured questionnaire for knowledge. A value of 1 and 0 was assigned for correct and incorrect practices respectively. For knowledge a value of 1 and 0 was assigned for correct and incorrect responses respectively. The total knowledge and practice score for each facility was calculated and then mean score was calculated. They were asked for their valuable feedback. Finally, they were thanked for their valuable support. Results: Only 12 (46.1%) of the doctors agreed that their facilities generate biomedical wastes, 15 (57.7%) of the doctors had opined that biomedical wastes associate with health hazard, 17 (65.4%) of the doctors were concerned regarding needle stick injury, 15 (57.7%) doctors believed wearing PPE reduces infection. Color coding of the waste segregation could be answered by 17 (65.4%) doctors, 13 (50%) of the doctors agreed that the BMW containers need to be labelled and 16 (61.5%) doctors agreed that the wastes need to be segregated at point of generation. Regarding color coded bins, 19 (73.1%) doctors practiced putting wastes in color coded bins. 20 (76.9%) doctors had the practice of displaying segregation instructions at their work place. 16 (61.5%) doctors were properly segregating wastes and aided in its proper transport. 18 (69.2%) doctors were not in practice of getting dustbins filled more than 3/4th. Conclusion: Findings from our study reveal that though the participants in our study have a fair knowledge regarding biomedical waste management still there is a lot of scope in not only improving the knowledge but also in changing the attitude and inculcating more rational practices towards the same. Majority of attendants had poor knowledge and practice regarding BMWM. Thus, there has to be a regular training programmes on biomedical waste management and its hazards for all the healthcare workers including group D workers. Along with educational intervention, strict implementation of biomedical waste management guidelines with its monitoring at all levels is also very much essential.