European Journal of Cardiovascular Medicine

Aim and Objectives: The aim of the study is to assess the role of altered lipid profile, lipoprotein (a) and serum magnesium levels in young patients with acute myocardial infarction (AMI). To evaluate the lipid profile in young adult patients with AMI and compare it with matched healthy adults; To determine the level of Lipoprotein (a) in young adult patients with acute MI and compare it with matched healthy control group; To estimate the level of serum magnesium in patients with acute MI and compare with healthy group. Methodology: The present study was a case-control study carried out at Owaisi hospital and research center and princess Esra hospital to detect the role of altered lipid profile, lipoprotein (a) and serum magnesium levels in young patients with acute myocardial infarction (AMI) and compared it with normal healthy controls of same age group. In the study, the most common risk factors found in young acute MI patients were smoking followed by psychosocial stress and family history of CHD. Results: This study revealed a male predominance in young adult cases with acute MI and maximum incidence of acute myocardial infarction was seen in the 4th decade of life. Serum lipid profile in this study revealed some significant alterations, there was a marginal increase in serum total cholesterol, serum triglycerides and serum LDL-c in young adult patients with acute MI. However, serum HDL-c levels were slightly lower in cases of acute MI compared to healthy controls. Serum Lp (a) levels were significantly increased in young AMI patients when compared to controls. This suggests that an elevated Lp (a) concentration is associated with AMI and a risk factor for acute MI in young adults Serum Magnesium levels in cases with acute MI were significantly decreased compared to controls. Magnesium is known to have an influence in the causation of acute myocardial infarction in young adults also. Conclusion: The present study concluded that  lipid fractions like total cholesterol, serum triglycerides (TG) low density lipoprotein (LDL) high density lipoprotein(HDL) cholesterol and lipoprotein (a) along with serum magnesium may be important for the pathogenesis of atherosclerosis. and could be considered as risk markers for acute MI in young adult population. But to prove this, it needs further large scale studies with large number of patients.