Contents
Download PDF
pdf Download XML
298 Views
116 Downloads
Share this article
Research Article | Volume 13 Issue:3 (, 2023) | Pages 1512 - 1517
To study the Effects of Trimetazidine on Left Ventricular Mechanics in Chronic Stable Angina Patients admitted in a tertiary healthcare center in north India
Under a Creative Commons license
Open Access
DOI : 10.5083/ejcm
Published
Sept. 5, 2023
Abstract

Background: A lot has been investigated about how trimetazidine (TMZ); a metabolic modifier works at molecular level, however very little is known about how well that translates into mechanistic benefit at LV muscular level. This study was done to evaluate the effects of trimetazidine on the LV mechanics in patients of chronic stable angina. Material & Methods: Hospital based observational study, we followed 40 patients of chronic stable angina on conventional optimal medical therapy (OMT). LV mechanical indices including 2D Global Longitudinal Strain (GLS),4D Global Circumferential Strain (GCS),4D Global Area Strain (GAS), 4D Global Radial Strain (GRS), LVEF, E/A, E/e’ were measured at baseline and compared 1 month after addition of TMZ to OMT.  Results: The mean 2D GLS at baseline was -17.36 ± 3.09%, which improved to -18.33 ± 3.13% on follow up (P=0.001). The mean 4D GCS at baseline was -6.87 ± 3.41%, and -8.52 ± 2.69% on follow up (P= 0.003). The mean 4D GAS at baseline was-12.40 ± 5.90% vs -14.02 ± 4.38% on follow up (P= 0.017). The mean 4D GRS at baseline was 16.50 ± 7.81% vs 18.00 ± 6.76% on follow up, P =0.091(NS). The mean LVEF improved from 55.67 ± 5.46 at baseline to 57.62 ± 5.15 on follow up after 1month on TMZ therapy (P=0.001). The mean E/A value at baseline was 1.14 ± 0.39, which changed to 1.04 ±0.24 on follow up (P=0.038). The mean E/e’ value at baseline was 8.91 ± 2.50, which improved to 8.14 ±2.17 on follow up (P=0.008). Conclusion: TMZ has beneficial effects on the LV Mechanistic indices when added over and above the conventional OMT in patients of chronic stable angina.

Keywords
Recommended Articles
Research Article
Study the effects of obesity on blood glucose levels in adolescents in Central Uttar Pradesh - An observational cross - sectional study
...
Published: 11/09/2025
Download PDF
Research Article
Evaluation of Ultrasonographic Strain Elastography in Differentiating Benign and Malignant Thyroid Nodules: A Histopathology-Correlated Study
Published: 11/09/2025
Download PDF
Research Article
Sugammadex Versus Neostigmine for Reversal of Rocuronium Block: Recovery Profile and Adverse Events- A Comparative Study
Published: 11/09/2025
Download PDF
Research Article
Prevalence and Associated Factors of Dysmenorrhea among College-Going Girls in Jhalawar District, Rajasthan
...
Published: 11/09/2025
Download PDF
Chat on WhatsApp
Copyright © EJCM Publisher. All Rights Reserved.