European Journal of Cardiovascular Medicine

Background: Chronic Myeloid Leukemia (CML) is clonal hematopoietic disease characterized by proliferation and expansion of myeloid cell lineages in bone marrow. It is a malignancy of considerable duration consisting of chronic phase followed by accelerated, and blast crisis phase.  Objective: To study the clinical, hematological, cytogenetic and molecular profile of CML.  Methods: This cross-sectional study was conducted in the department of Medicine and Oncology, KR hospital, Mysore Medical College and Research Institute, Mysore during the study period of one and half year from January 2020 to July 2021.  Results: The mean age of presentation was 44.5. There was slight male preponderance with Male: female ratio of 1.41:1. Cigarette smoking was seen in 31% patients which was statistically insignificant. An incidental diagnosis was made in 1 person. Anemia, thrombocytosis, leukocytosis and massive splenomegaly were striking features. The peripheral blood smear showed shift to left with spectrum of myeloid cells with varying degree of differentiation. Basophilia was striking in all the cases (100%). The bone marrow showed marked hypercellularity with increased M:E ratio. Majority of the patients were in CML-CP phase followed by 1 patient in AP phase and none in blast phase. Majority of the patients had standard Ph positive CML. Conclusions: The present study highlights that cytogenetics play a vital role in diagnosing and prognosticating CML and also the importance of routine health check-up.