Background: Mechanical systolic LV dyssynchrony is associated with poor outcomes in patients with cardiac failure. However, its role in predicting prognosis after acute MI has been remotely explored. Materials and methods: 62 patients with acute MI who were admitted to the Department of Cardiology, Govt General Hospital, Ongole were included in this study. All patients were subjected to echocardiography and their baseline parameters were noted. The patients were followed up for 6 months. Results: Dyssynchrony is present in 35% of the study population. The prevalence of dyssynchrony is significantly higher in AWMI compared to nonAWMI. Baseline LV dyssynchrony of 57 ms or more, as assessed by TDI, had a sensitivity of 94% and a specificity of 84% to predict LV remodeling at 6 months after acute infarction. Conclusion: Early identification of LV dyssynchrony aids in understanding the prognosis after acute MI and helps in intervening before the start of LV remodeling.