European Journal of Cardiovascular Medicine

Introduction: Hypertension is the major health problem observed throughout the world. Hypertension, along with pre-hypertension and other hazardously high blood pressure, is responsible for 8•5 million deaths from stroke, ischaemic heart disease, other vascular diseases, and renal disease worldwide. If untreated it may cause stroke, end stage renal failure and heart attack. For the treatment of hypertension, there are different classes of antihypertensive drugs that control blood pressure by acting through different mechanisms. The main aim of the study to determine a suitable monodrug therapy for the treatment of hypertension.  Material and methods: Present study was carried out on 186 hypertensive patients. Based on the inclusion criteria patients were divided into five groups and prescribed Atenolol, Azilsartan, Chlorthalidone, Diltiazem, and Enalapril as mono-drug therapy. All the parameters like systolic, diastolic blood pressure, heart rate, total cholesterol, and triglycerides were estimated and noted at baseline and after 3 months of treatment, all the parameters were estimated and noted as after 3 months of treatment respectively.  Results: The majority of the patients were male with the age group of 51 to 60 years. 15.05% were not having complications and 84.94% had complications. Based on the complication majority were having Hyperlipidemia followed by diabetes mellitus. Based On the treatment in groups A, B, C, D & E showed a significant mean reduction in systolic and diastolic blood pressure. A significant mean reduction in heart rate was observed in groups A, B & D whereas no significant mean reduction in heart rate was observed in groups C and E. No significant change was observed in total cholesterol and triglycerides in all five groups respectively.  Conclusion: Monodrug therapy with antihypertensive drugs shows better improvement in systolic and diastolic blood pressure, with few groups showing significant reduction in heart rate and whereas no effect on lipid profile.