European Journal of Cardiovascular Medicine

Background: Post operative nausea and vomiting is one of the commonest complication following General Anaesthesia resulting in delayed discharge, pathological and physiological distress for the patients.

Materials And Methods: Patients were subjected to a thorough PAE, and routine investigations were done. After obtaining approval and clearance from institutional ethical committee, patients fulfilling criteria and willing to give informed written consent were included in the study and were divided into 2 groups with 30 patients in each group –

1. Group A – patients receive Tab Pregabalin 150 mg orally 1 hour before surgery as premedication with 1 spoon of water.

2. Group B – patients receive a placebo drug.

In preoperative area, baseline vitals were recorded and Patients received 150 mg of tab pregabalin as premedication 1 hour before the surgery. Patients were given premedication with Inj Midazolam 0.05mg/kg body weight, Inj Glyclopyrolate 60mcg/kg body weight. Patients were induced with Propofol 2mg/kg body weight and fentanyl 3mcg/kg body weight. Preoxygenated with 100% O2 for 3–4 mins and vecuronium at 0.1mg/kg body weight was used as muscle relaxant. Patients were intubated with appropriate size E.T Tube and fixed and connected to ventilator and maintained with O2 (60%)+ Nitrous oxide (40%) + Isoflurane (0.8 – 1%) + Vecuronium 0.08mg/kg body weight.

30 mins before extubation 5 HT 3 antagonist Ondensetron 0.15mg/kg body weight was given.

Number of post operative nausea vomiting episodes were recorded by Nausea as primary aim and pain score, hemodynamic stability with Heart rate, blood pressure were recorded as secondary aim.

Results: The comparative study between the two groups showed statistically significant results favoring the primary objective. The oral pregabilin dose of 150 mg produced significant reduction in post-operative nausea and vomiting (PONV). [Chi square 11.29, P value: 0.001 table 11]. The statistical analysis also significantly showed that the pregabilin group had less post operative pain, complications of vomiting and other symptoms. [chi square 1.429, P value <0.00, table 12]. The additional benefit of post operative pain relief determined via VAS score was also statistically in the oral pregabilin group. [chi square 60.0, P value <0.001, table 13]. However, the demographic composition of two groups were insignificant on (age, sex, weight) on statistical analysis. The heart rate response and the response on blood pressure (SBP and DBP) during the intubation process in the oral pregabilin group was significantly less and hence better in obtundation of the response to intubation [Table 7,8,9,10]. The sedative effect of pregabalin group assessed post operatively showed significant sedation and hence the additional benefit of post-operative analgesic effect too.  Conclusion: We conclude that pre-operative pregabalin is associated with significant reduction of post operative nausea and vomiting, and it can be considered as a part of multimodal approach to post operative nausea and vomiting and also for post operative analgesia.