European Journal of Cardiovascular Medicine

Background: Acute Pancreatitis is associated with nearly 20% of the morbidity and mortality and the need for a critical care bed, nutritional support, urgent ERCP and antibiotic usage to combat the severity even then about 25% of patients with acute pancreatitis will develop severe acute pancreatitis (SAP) and is strongly associated with organ failure and local complications such as peripancreatic fluid collections, pancreatic or peripancreatic necrosis (sterile or necrotic), formation of walled-off necrosis (sterile or infected) or pseudocyst etc.  the present study was chosen to observe and understand the clinical course and the outcome of Acute Pancreatitis induced either by alcohol or gallstones comparatively so that it will help the patients for better management and to reduce the severity, morbidity and mortality associated with Acute Pancreatitis. Research Question: What is the clinical course and outcome of Acute Pancreatitis induced either by alcohol or gallstones comparatively in our setup?  The setting of the study was at department of Gastroenterology, Government General Hospital, Guntur Medical College, Guntur, Andhra Pradesh. A one year observational study was conducted during the period from January 2022 to December 2022 on about 100 Acute Pancreatitis cases admitted during the above period in the department of Gastroenterology  by studying their socio-demographic profiles, associated comorbidities, assessing the degree of severity, clinical course and outcome, and complications etc. Results: It was observed that maximum males (88.23%) were observed in Alcoholic AP whereas maximum (81.25%) females were observed in Gallstone AP which was statistically highly significant and among the patients with alcoholic AP about 48.52 % patients were in the age group of 36 – 45 years when compared to 15.62 % in gallstone AP whereas 31.25 % patients were in the age group of 26-35 years in gall stone AP when compared to 16.17 % in alcoholic AP which was statistically significant. And also it was observed that the percentage of patients with more than 56 years age group were more in gallstone AP group when compared to other group which was  statistically not significant. There was no significant difference in mean age between the two groups but male patients were higher among alcohol AP than gallstone AP significantly. It was understood that regarding total hospital stay and number of days in ICU after surgery Alcohol induced AP is significantly better than Gallstone induced AP but in other parameter NPO days (nothing per oral) both were same. Related to distribution of comorbid conditions and local complications no significant difference was observed (P>0.05) and regarding intervention procedures ERCP was more in Gallstone AP & Cystogastrostomy was more in Alcoholic AP significantly. With reference to Lab findings serum creatinine levels was equal in both the groups but significantly serum amylase levels were high among Gallstone group comparatively. And also mortality was observed significantly high among Alcoholic AP group (6%).