European Journal of Cardiovascular Medicine

Background- Cervical cancer is a preventable disease and it is the second most common malignancy world wide and major cause of mortality in developing countries1.In developing countries it accounts for 15% of all new female cancer with an estimated 5,00000 new cases and 2,75000 death 1.In developing countries it account for 15% of all new female cancer with an estimated 5,00000 new cases and 2,75000 death 1 In India every year 122,844 women are diagnosed with cervical carcinoma and 67,477 dies from the disease 1 Objectives  - The present study intends to see expression of EGFR-1 in Squamous cell carcinoma of cervix and correlate it with histological grade and patient’s age. This study will help in planning the  therapeutic approach in patients with cervical carcinoma and also prognosis. Method-In present study  52 cases of Squamous cell carcinoma of cervix  were studied  in  Department of pathology ,MR.Medical college attached to BTGH hospital KALABURAGI and in various   private labs of kalaburagi  from September 2015 to August 2017. Membrane Positivity will be scored according to DAKO criteria   and   cyto plasmic and nuclear positivity will be scored according to percentage and intensity score  Results–  Fifteen cases of well differentiated Squamous cell carcinoma of cervix showed weak expression & thirty cases of moderately differentiated Squamous cell carcinoma of cervix showed moderate to strong expression,Seven patients of  poorly differentiated squamous cell carcinoma of cervix patients showed Strong expression of EGFR- 1 in patients  aged group of 45 to 60 years. Conclusion –  This study showed strong expression of EGFR-1 in poorly differentiated  squamous cell carcinoma of cervix in patient  aged from  fourth to sixth decade of life .And need for  aggressive management and treatment of cervical carcinoma patients.