European Journal of Cardiovascular Medicine

Introduction: Diabetic foot ulcer is characterized by several pathological complications such as neuropathy, peripheral vascular disease, foot ulceration and infection with or without osteomyelitis, leading to the development of gangrene and even necessitating limb amputation. The study aims to study the prescription pattern and effect of antidiabetic drugs on diabetic foot ulcer patients.  Material and methods: A prospective observational study was conducted at the Department of General Medicine for one year the data was collected from 112 patients using a data collection form. The patients were selected based on inclusion and exclusion criteria and after permission from the institutional ethical committee.  Results: As per the study majority of the patients were male (76.78%) under the age group of 61 – 70 years (52.67%).  as per demographic status, 70.53% were non-smokers, 59.82% were alcohol drinkers and 82.14% of patients were both smokers and alcohol drinkers and  63.39% of patients were having a family history of diabetes. Based on the location of ulcers on foot were graded as 1, 2,3,4 & 5 grades, as per our study 41.96% had grade 4 ulcers. The majority of the patients were prescribed with dural drug combination therapy of antibiotics 47.32% followed by triple drug combination of antibiotics 27.67%, multiple drug combination therapy 19.64% and 05.35% monodrug therapy respectively, as per the prescription pattern of antibiotics Metronidazole 30.35% followed by Piperacillin + Tazobactam 23.23%, ciprofloxacin 16.96%, Vancomycin 11.60%, Ceftazidime 06.25%, Ampicillin and Doxycyline 04.46% and Gentamycin 02.67%. As per our study majority of the patients were prescribed metformin + glimepride + insulin 56.25% followed by metformin + glimepride 24.10%, metformin + tenegliptine 11.60% and metformin + pioglitazone 08.03% respectively. A higher significant mean reduction was observed in metformin + glimepride + insulin-treated groups (p<0.005).  Conclusion: As per our study Metronidazole antibiotic and a combination of metformin + glimepride + insulin show better control over blood glucose levels in patients suffering from diabetes.