European Journal of Cardiovascular Medicine

Background: In the Emergency Department, COPD patients are assessed clinically and categorized with different grades of severity of the disease. Aim: To analyze the factors predicting failure of non invasive ventilation in Emergency Department among the patients with acute exacerbation of chronic obstructive pulmonary disease. Methodology: It was a prospective cohort study carried out during the period from July 2022 to August 2023. A total of 82 patients with acute exacerbation of chronic obstructive pulmonary disease requiring NIV attending Department of Emergency Medicine Results: In the present study 71.95% of the patients were males and 28.05% of the patients were females. The male female to ratio was 2.56:1. In this study 52.44% of the patients had hypertension, 42.68% of the patients had diabetes mellitus. The other comorbid conditions are as shown in table 5.3 and graph 5.3. In this study all the patients had shortness of breath and cough (100.00%) while fever was noted in 70.73% of the patients. In the present study failure of NIV and requirement of intubation was noted in 4.88% of the patients. In this study NIV failure was significantly associated with patients having pre existing or pulmonale (p=0.017) and hypothyroidism (p=0.025). In this study with regard to temperature (p=0.042), PO2 pertaining to second ABG analysis (p=0.023), NIV tidal volume (p=0.031) and hospital stay (p=0.001) differed significantly in patients with and without NIV failure. Conclusion: Based on the findings of this study it may be concluded that, the rate of NIV failure was low (4.88%) in a carefully selected patient population with timely intervention and strict monitoring.