Aims and objectives:The current study aims to find the correlation of serum CRPlevel with disease morbidity & clinical recovery in patients with acute ischemic stroke Materials and methods: A prospective observational study was conducted in 80 radiologically confirmed cases of acute ischemic stroke admitted in medicine wards at Dr Baba Saheb Ambedkar Hospital,Rohini,New Delhi. Patients were subjected to detailed neurological examination and blood samples were obtained from patients who fulfilled the inclusion and exclusion criteria and blood was send to laboratory for the measurement of serum CRP levels. Results: In this study group, the serum CRP levels on admission were predictive of stroke severity(positively correlated with NIHSS (P = 0.001) as well as outcome(positively correlated with MRS(P =0.001) Conclusion: The serum CRP level on admission can be used to predict severity and outcome in acute ischemic stroke