Background: Chronic kidney disease (CKD) has emerged as a significant global health problem with substantial morbidity, mortality, and economic burden. The prevalence of CKD varies across different regions, with a higher burden observed in low- and middle-income countries.CKD is often associated with a range of comorbidities, including hypertension, diabetes mellitus, cardiovascular diseases, and anemia, which further contribute to adverse outcomes.Understanding the etiology of CKD is crucial for implementing targeted prevention and management strategies.Objective: To assess the clinical profile of CKD Patients. Methods: This cross sectional study was done on 100 CKD patients after IHEC approval with Informed consent. The various etiology of CKD, stage of disease, coexisting medical conditions, laboratory findings, and ECG/ECHO were measured.Result: Anaemia and hypocalcemia was common among the study participants. All had Cardiac changes. Majority of patients had comorbidities such as alcoholism, cardiac disease, anemia, clubbing, pedal edema, and abnormal lipid profiles. Conclusion: Managing anemia, mineral and bone disorders, fluid and electrolyte balance, hypertension, dyslipidemia, and inflammation becomes crucial in the comprehensive care of CKD patients to mitigate cardiovascular risks.