European Journal of Cardiovascular Medicine

Introduction: Deep Vein Thrombosis (DVT) is the third most common vascular disease after myocardial infarction and ischemic stroke. DVT is a multi-factorial disorder with many inherited and acquired risk factors playing in its etiopathogenesis. Homocysteine (Hcy) is a sulphur-containing amino acid which plays a vital role for development of the tissues. Hyperhomocysteinemia is a disorder of methionine metabolism and a modifiable risk factor of myocardial infarction, peripheral arterial thrombosis as well as deep vein thrombosis and pulmonary embolism. Increasing prevalence of DVT worldwide causes increased morbidity & mortality & have increased economic burden in the community. Pathogenesis of DVT may be associated with the destruction of vascular endothelial cells resulting from immune and inflammatory mediators.mStudies about the role of Homocysteine in the pathogenesis of vascular thrombo embolism, shown conflicting results hence any reliable clue will be considered valuable. Aims & Objective: To estimate serum Homocysteine in female DVT patients and to assess the relation between hyperhomocysteinemia and deep vein thrombosis. Materials and Methods: This cross-sectional study included 60 female patients of DVT. Venous blood sample was collected in heparinized vial and analyzed for homocysteine levels. Results: In our study we found significantly raised serum homocysteine levels (p value <0.05) in females belonging to more than 40 yrs. of age as compared to the other age group. Conclusion: In our study we found that women are more susceptible to the pathological effects of elevated homocysteine levels in age group more than 40 yrs. which may be a risk factor for DVT