European Journal of Cardiovascular Medicine

Introduction: Diabetes mellitus is the most common endocrine disorder of humans characterized by metabolic abnormalities leading to long term complications involving kidneys, gastrointestinal tract, nerves and blood vessels, thereby causing morbidity and mortality. Human diabetic neuropathy is characterized by dysfunction of somatic and autonomic nervous system. A simple definition it Was recently agreed on at an international consensus meeting. “The presence of symptoms and/ or signs of peripheral nerve dysfunction in people with diabetes after the exclusion of other causes”. Vagal innervation of the heart is essential efferent pathway to sustain this variation which is decreased as age advantage due to lowered vagal tone. Asymptomatic but striking reduction or absence of this variation is observed in autonomic neuropathy.  Materials And Methods: Diabetes mellitus patients who have been attending Department of General Medicine, Subbaiah Institute of Medical Sciences, Shivamogga, Karnataka from January 2022 to December 2022 were taken for study considering the inclusion and exclusion criteria. This is a cross sectional study. All the Selected patients will be investigated with RBS, FBS, PPBS, HbAIc for glycemic control. Ultrasonography was done to study the fasting gall bladder volume in patients. Cardiac autonomic neuropathy will be assessed clinically by using simple non invasive bed side tests like heart rate variation during to standing, deep breathing.  Results: The youngest patients was 41 years old and the oldest was 76 years old. The maximum number of patients were in the age group of 41-50 ( 55%). Mean age in the present study was 52.6 years. In our study 60 (75%) were male and 20 (25%) were female. In the present study the mean gall bladder volume in diabetes with diabetic Severe autonomic neuropathy was 55.8 + 9.9ml and as a whole mean gall bladder volume in persons with autonomic neuropathy was 30.13 ± 18.73ml and the mean gall bladder volume in diabetes without diabetic autonomic neuropathy was 18.5 +5.01ml. P value is <0.05 there is statistically significant correlation between diabetic autonomic neuropathy and Gall bladder volume. Conclusion: The gall bladder volume was significantly higher in diabetic patients with autonomic neuropathy when compared to diabetics without autonomic neuropathy. Diabetic autonomic neuropathy was seen in diabetic patients who had poor glycemic control when compared to those who had good glycemic control. The gall bladder volume was more in diabetic patients with higher age group patients. A definite association of cardiac autonomic neuropathy with cholecystomegaly has been established by our study.