European Journal of Cardiovascular Medicine

Background and Objectives: The aim of this was to present our firsthand observations and findings pertaining to the occurrence of acute kidney injury (AKI) subsequent to exposure to toxic substances. Methods: This retrospective study involved the collection of data from patient case records at a prominent nephrology hospital situated in central India. Patient records were carefully examined to obtain information regarding the ingested substance, symptoms observed upon presentation, basic laboratory test results obtained upon admission, the treatment modality employed, and the ultimate outcome. It is important to note that patients who developed AKI following snake envenomation or scorpion stings were specifically excluded from this study. Results: A total of 200 cases involving AKI resulting from poisoning were identified. The largest group within this cohort consisted of patients who were affected by paraphenyline diamine poisoning. Additionally, there were cases of methanol poisoning, organophosphorus compounds, paraquat, and copper sulphate poisoning, tartaric acid poisoning, phenobarbitone poisoning. Notably, 9 patients had ingested a combination of multiple substances. Among the affected patients, 95% required renal replacement therapy. Overall, 70% of patients achieved complete recovery, while 30% succumbed to the acute phase of the illness. Conclusion: The reporting of toxic substances that lead to the failure of vital organs is of utmost importance in order to enhance awareness among the general population and healthcare providers. By providing comprehensive documentation and dissemination of information regarding these substances, the understanding of the potential hazards associated with them can be improved.