European Journal of Cardiovascular Medicine

Introduction: When a baby has polycythemia, it is indicated by a central venous Hct more than 65% or a haemoglobin level greater than 22 g/dl. Increased viscosity leads to a reduction in tissue oxygenation and perfusion as well as a propensity for micro thrombi to develop. If these things happen to the kidneys, adrenal glands, or cerebral cortex, serious harm might result. Therefore, this problem has to be diagnosed and treated very away, although the best replacement fluid is still up for debate. to measure the haematocrit at 0, 6, and 24 hours following a partial exchange transfusion using fresh frozen plasma and normal saline, and to compare the outcomes in the two groups. Material & Method: From October 2016 to September 2018, the study was conducted at the newborn care unit of the Department of Paediatrics at VIMSAR Burla. For this andomised controlled experiment, which included two arms—the NS arm (neonates in whom NS was used as replacement fluid for PET) and the FFP arm (neonates in whom FFP was used as replacement fluid)—29 newborns who met the inclusion criteria were enrolled. After six and twenty-four hours after exchange transfusion, the different parameters were examined and compared between the groups. Result: The hematocrit and haemoglobin levels assessed six and twenty-four hours after PET did not, on the whole, differ significantly between the two groups. As with other criteria, there was no discernible difference between the two groups. In contrast to the FFP group, the NS group experienced a shorter time between diagnosis and treatment, which was shown to be significant (p value<0.00). The costs associated with utilising FFP were higher than those of NS, which was also statistically significant. Conclusion: There was no statistically or clinically significant difference seen between fresh frozen plasma and PET with normal saline, indicating that both are equally safe and effective. In comparison to FFP, normal saline was less expensive, more accessible, and more useful in the treatment of newborns with polycythemia; as such, it ought to be regarded as the perfect alternative fluid for PET.