European Journal of Cardiovascular Medicine

Introduction: Regional anesthesia is preferred for cesarean section as it allows a parturient to remain awake and participate in the birth of her baby while avoiding the risks of general anesthesia. The combined spinal-epidural (CSE) technique is frequently used to provide anesthesia and analgesia for labor and delivery. To improve the quality of intraoperative anesthesia, postoperative analgesia and aid early ambulation and recovery of motor block, several agents have been employed such as opioids and α-2 adrenergic agonist. Some recent placebo-controlled studies suggested that α-2 adrenergic agonist have both analgesic and sedative properties when used as an adjuvant in regional anesthesia.  Materials and Methods: After obtaining written consent from the 180 patients, they were randomly divided into three groups of thirty each. All the patients were pre-operatively assessed and the technique for study was explained to them. Patient’s age ranging from 25 to 60 years, of either sex, belonging to ASA I and II and no contra-indications to epidural analgesia or the drugs were taken into consideration. The three groups were comparable in terms of baseline demographic parameters like age, sex, and weight. Basal haemodynamic parameters were comparable. Patients of ASA III and above, allergic to study drugs were excluded from the study. Results: 180 patients were enrolled in the study. In group A, 60 patients, in group B 60 patients, in Group C 60 patients. In group A, 34 patients were male, 26 patients were females, In group B, 32 patients were male, 28 patients were females. In group C, 30 patients were male, 30 patients were females. Analgesia and sedation was more in Group C than the other two groups. Cardiovascular stability was good in groups A and B. Conclusion: Since sensitivity to a drug depends on numerous factors, the search for an ideal dose in endless. We found that epidural dexmeditomidine 50 mcg dose gave satisfactory analgesia and sedation with minimal side effects.