Introduction: Injury is defined as physiological damage to living tissue caused due to physical stress. It can be intentionally or unintentionally, caused by blunt and penetrating trauma, burning, toxic exposure, or overexertion. This injury can occur in any part of the body with different symptoms related to different injuries. Computed tomography (CT) most commonly used diagnostic technique specifically used for organ and tissue damage, whole-body CT is used as a standard diagnostic technique. An autopsy is the final diagnostic examination and is considered a standard diagnostic methods in medicine. The study aimed to compare CT scan results, with autopsy results for forensic purposes. Material and method: The present study was retrospective–a prospective study carried out on 500 injured patients attending OPD of general medicine Patient's informed consent was taken. Their age, gender, cause of injury, different areas of injury, conciseness, unconciseness, death, and complication in conciseness patients were noted. Results: as per the study majority of the patients were male with the age group of 40 – 60 years. The majority of the patients were conscious having vertigo and bleeding, and were injured due to transport accidents. 84 patients having head injury among them brain death was observed in most of the patients having positive results over CT and autopsy technique. Conclusion: A CT scan compared to an autopsy is a good method for detecting gunshot injury of head and bone fractures. Were as the autopsy is better for detecting minor injuries to organs and soft tissues.CT and Autopsy are the best techniques for most injury cases.