European Journal of Cardiovascular Medicine

Role of Vitamin D for intestinal absorption of calcium is well known. Deficiency causes musculoskeletal conditions osteoporosis and rickets. The involvement of Vitamin- D in the immune reaction is well established as it facilitates enhancement and regulation of immune mechanisms both innate and acquired in various tissues including lung. Its activation has potent antiproliferative, pro-differentiative and immunomodulatory functions. These properties of Vitamin D got attention in recent years with regards to chronic diseases like COPD and other lung pathology. Present study aim to correlate vitamin D and COPD. Objectives: 1-To estimate serum vitamin D level in COPD (Chronic Obstructive Pulmonary Disease) patients and compare it with controls (normal healthy adults). 2. To compare serum vitamin D level with severity of COPD in these patients. Material and method: Single-center randomized cross-sectional study done at a tertiary care centre which includes 100 Patients of aged between 40-60 years with diagnosis of COPD on the basis of clinical and radiological sign and symptoms with Spirometric criteria (FEV1/FVC - <0.7, % FEV1 <80%). COPD patient further categorized into GOLD grade 1,2,3 and 4 on the basis of severity and compared there vitamin- D levels separately and tried to correlate it with severity of disease.103 Controls were taken includes healthy subjects of age 40-60 years. Interventions: We measured total serum 25-(OH)-D by Diasorin competitive radioimmunoassay (RIA) (AID Diagnostika, GmbH, Strasburg, Germany) at study centre. Results: The mean Serum Vitamin 25-(OH) D of COPD patients was 19.4 ± 7.9 ng/ml, Among controls it was 30.5 ± 8.6 ng/mL.( p <0.05). On the basis of severity of COPD, serum levels of Vit D are, 31.30 ± 11.69, 18.56 ± 5.36, 18.79 ± 6.81 and 16.82 ± 7.30 ng/md in COPD grade 1,2,3 and 4 respectively with p<0.05. Conclusions: Low Vitamin D was highly prevalent among COPD as compared to general population in same geographical area and Vitamin- D insufficiency increases with progression of COPD.