European Journal of Cardiovascular Medicine

Objective- Creatinine, the anhydride of creatine is formed largely in muscle by irreversible non-enzymatic dehydration of creatine phosphate. The 24 hours excretion of creatinine in the urine of a given subject is constant from day to day and proportionate to muscle mass. Materials and Methods- A total of 396 healthy subjects of whom 286 were male and 110 females and age ranges from 20 – 60 years were included in the study are compared with established interval. Estimation of serum creatinine level of all received samples was detected by enzymatic methods in fully automated analyser machine. Result-The calculated reference interval for serum creatinine level was 0.4 - 1.3 mg/dl and 0.6 to 1.3 mg/dl in the age groups of 21- 40 and 41- 60 years respectively.Conclusion-The present study has shown a variation in mean values of normal serum creatinine level. The difference between the mean serum creatinine value in total males and total females was statistically significant.