European Journal of Cardiovascular Medicine

IBackground: The prime challenge of physicians in 21st century is cardiovascular disease (CVD). Cardiovasculardisease principally ischemic heart disease and stroke are the leading cause of mortality and majordisability in the world. The most important modifiable risk factors of CVDs are dyslipidemia, obesity and hypertension. The effects of unhealthy diet and physical inactivity include abnormal blood lipids, obesity and hypertension. Objective: To evaluate & correlate the pattern of lipid profile & blood pressure in obese & non-obese patients. Materials and methods: This is a cross-sectional study based on a database of 180 adults who received routine health screening. Subjects (n=180) include both male and female age between 20- 50 years who were willing to participate in the study, having body mass index (BMI) > 18.5 kg/m2,were considered. Subjects who are known case of obesity secondary to hypothyroidism, Cushing’s syndrome, hypothalamic disease, pregnant, congestive cardiac failure, renal failure, cirrhosis withascites and those on lipid lowering drugs or any drugs affecting lipid metabolism were also excluded. Subjects who are on antihypertensive drugs were also excluded. Statistical analysis: The data are expressed in numbers as means ± SD. The t test was used to compare continuous variables, such as obesity indicators and biochemical parameters, between the two groups. Statistical analyses were performed using SPSS version 26.0 (SPSS Inc.,). A p value < 0.05 was considered statistically significant. Result: Blood pressure was elevated in Gr-III as compared to Gr-I+II (p<0.001). Serum Cholesterol, triglycerides, LDL, VLDL were elevated in Gr-III as compared to Gr-I+II (p<0.001).HDL was decreased in Gr-III compared Gr-I+II (P<0.001). In our study shows comparison of lipidprofile parameters and blood pressure parameters between nonobese (Gr-I+II) and obese subjects(Gr-III). Elevated cholesterol, triglycerides, LDL, VLDL in Gr-III as compared to Gr-I+II. It also shows elevated blood pressure parameters in Gr-III compared to Gr-I+II. Conclusion: Obese persons are prone to develop elevated serum cholesterol, triglyceride, LDL and VLDL cholesterol as compare to non-obese. There is a positive correlation of serum cholesterol, triglyceride, LDL and VLDL level with body mass index in this study, and there is negative correlation of serum HDL level with body mass index. The mean values of blood pressure parameters are more in obese subjects as compared to non-obese subjects.