European Journal of Cardiovascular Medicine

Background: Essential Thrombocytosis is a clonal hematopoietic stem cell disorder that causes increased platelet production. Patients are at risk of microvascular thrombosis and hemorrhage. Essential Thrombocytosis is a diagnosis of exclusion. We reported a case of Essential Thrombocytosis in 42 years female, where initial platelet count of 17 lakhs was reduced to post procedure count of 7.6 lakhs. Treatment consists of aspirin, platelet-lowering drugs (e.g., hydroxyurea, interferon, anagrelide), plateletpheresis, cytotoxic agents & rarely stem cell transplantation. The most important first step in the management of ET is to confirm the accuracy of the diagnosis and make sure that other myeloid neoplasms, which might mimic Essential Thrombocytosis in their presentation are excluded.