European Journal of Cardiovascular Medicine

Background: Dengue fever is a significant global health concern, particularly affecting children in tropical regions. This study aimed to comprehensively analyze the laboratory profiles of serologically proven dengue cases in children and their associations with clinical outcomes. Materials and Methods: A prospective observational study was conducted on 300 pediatric patients with suspected dengue fever. Demographic data, clinical symptoms, serological markers (IgM and IgG antibodies, NS1 ELISA), and laboratory parameters were analyzed. Associations with disease severity and clinical outcomes were explored. Results: High prevalence of dengue-specific IgM antibodies (91.7%) and IgG antibodies (63.3%) was observed, with 50% of cases indicating secondary infections. NS 1 antigen ELISA was positive in 40% of cases. Clinical symptoms included fever (91.7%), headache (80%), myalgia (60%), and bleeding manifestations (16.7%). Severe forms of dengue (DHF/DSS) accounted for 30% of cases. Hemoglobin levels were lower in DHF/DSS cases (10.5 g/dL) than in non-severe cases (9.8 g/dL). Platelet counts were significantly lower in DHF/DSS cases (110 × 10^3/µL) compared to ICU admissions (85 × 10^3/µL). Serum creatinine levels were slightly elevated in ICU admission cases (1.1 mg/dL) compared to DHF/DSS cases (0.9 mg/dL). Conclusion: This study highlights the importance of serological markers and laboratory parameters in diagnosing dengue and assessing disease severity in pediatric cases. Early diagnosis and monitoring of these markers are crucial for timely clinical intervention. Further research is needed to validate these findings and enhance our understanding of pediatric dengue pathophysiology.