European Journal of Cardiovascular Medicine

Background: Pre-existing hypertension, renal disease, diabetes mellitus, Obstructive Sleep Apnea, thrombophilia, and autoimmune disease all enhance the chance of developing hypertensive disease during pregnancy by decreasing uteroplacental blood flow. Women with a history of preeclampsia, HELLP syndrome, twin pregnancies or other multiple pregnancies, a BMI >30, autoimmune disease, being over 35 years old, being first-time mothers, or having a sister or mother who had hypertension during pregnancy are at an increased risk of developing hypertensive disorder of pregnancy and pre-eclampsia. Objectives: To evaluate the screening efficacy of urinary calcium creatinine ratio versus Doppler study in predicting pre-eclampsia. To study that low urinary calcium creatinine ratio (UCCR) of < 0.04 in asymptomatic pregnant women association with subsequent development of pre-eclampsia. To study the usefulness of uterine artery Doppler velocimetry as a predictor for pre-eclampsia before 20 weeks in asymptomatic pregnant women. Material & Methods:  Study Design: Hospital based observational study. Study area: Department of Obstetrics & Gynecology, in a tertiary care teaching hospital. Study Period: April 2022 – March 2023. Study population:  Normotensive nonproteinuric pregnant women less than 20 weeks attending the outpatient as well as antenatal ward. Sample size: Study consisted a total of 100 subjects. Sampling Technique:  Simple Random technique. Study tools and Data collection procedure: A hospital based prospective comparative study was conducted among a group of 100 normotensive nonproteinuric women 11 to 14 weeks attending the outpatient as soon as antenatal ward in tertiary care teaching hospital over a period of one years. They are subjected to a detail history and general examination. Results: Out of 100 women, 33 had abnormal PI at 11-14 weeks and out of which 24 developed Pre-Eclampsia. The sensitivity is 100% and specificity are 88.2% positive predictive value is 72.7%and NPV is 100% and its association between preeclampsia was statistically significant (p value<0.0001). Out of 100 women, 58 had abnormal PI at 16-20 weeks and out of which 23 developed Pre-Eclampsia. The sensitivity is 95.8%and specificity are53.9%, positive predictive value is 39.7 %and negative predictive value is 97.6% and its association between preeclampsia was statistically significant (p value<0.001). Conclusion:  We conclude that PI at 11-14 weeks and 16 – 20 weeks was found to be the better predictor of Preeclampsia compared to UCCR with better sensitivity, specificity and diagnostic efficacy. We recommend using PI at 11-14 weeks as the predictive tool to predict the development of preeclampsia.