European Journal of Cardiovascular Medicine

Background:  Acute myocardial Infarction (AMI) is one of the leading causes of mortality in both developed and developing countries.The prevalence of obstructive coronary artery disease is lower in women despite the greater magnitude of myocardial ischemia and associated mortality in comparison with men. These gender-based differences can be attributed to genetic, hormonal differences and the differences acknowledged to exist at cellular levels. Methodology: This is a retrospective observational study of 625 patients presented with STEMI and who underwent coronary angiography over 1 year period from July 2022 to June 2023 at King Geroge Hospital, Visakhapatnam with the objective of assessing the differences in clinical profile, risk factors and coronary angiographic profile of STEMI patients among men and women. The Data regarding demographic characteristics, coronary risk factors (smoking, hypertension, and diabetes mellitus), and other comorbidities (body mass index (BMI)] was collected in patients with STEMI. Data was analyzed using the MS Excel, SPSS version 21. The Chi‑square test, unpaired t test and Fisher’s exact test were used to assess the significance of variables. Results: Among 625 STEMI patients, 407 patients were males and 218 were females with male preponderance which is statistically significant. The mean age of presentation of males and females was 54.3 yearsand 58.8 years respectively. Women are on average older than men. More of the younger women were presented with STEMI than men. Among risk factors, hypertension and smoking were the most common risk factors for men. Hypertension was most common risk factor in women with statistical significance compared to men, whereas smoking was statistical significance in men compared to women. There was no much difference in BMI of men and women. Anterior wall MI was the most common clinical presentation in both men and women.  Conclusion: On angiography, TVD and LMCA+DVD involvementwas more in women than men with statistical significance. Mild CAD was more common in men compared to women with statistical significance. LAD was the most common vessel involved in both men and women.