European Journal of Cardiovascular Medicine

Introduction: Psoriasis is a systemic inflammatory disorder that involves complex pathogenic interactions between the innate and adaptive immune systems. Individuals with psoriasis have an increased risk of developing other chronic health diseases such cardiovascular disorders. The high incidence of cardiovascular events in the population with psoriasis could be explained by several mechanism. The high prevalence of traditional cardiovascular risk factors and metabolic abnormalities contributes to the high cardiovascular burden in patients with psoriasis. The most prevalent and chronically inflammatory dermatologic condition is psoriasis. Although it is connected to several illnesses, cardiovascular disease is the most prevalent. There is a critical need to analyze lipid abnormalities in psoriatic patients to determine the level of risk that individuals may experience for developing atherosclerosis, vascular obstructive disorders, associated morbidity and mortality. Aim: To estimate lipoproteins levels & related risk of cardiovascular diseases in psoriasis patients. Materials and Methods:This cross-sectional analytical study was carried out at Dr. D. Y. Patil Medical College & Hospital in Pimpri, Pune. 40 psoriatic patients with a mean age of 50.68 ± 8.86 years made up the study group, and 40 healthy people of either sex with a mean age of 50.15 ± 9.6 years made up the control group. Enzymatic End Point Method was used to estimate the levels of serum total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol on the same day. By computing the mean, standard deviation, p-value, and Chi-square test, the data was analyzed. Results: Findings of this study showed that, compared to the control, total cholesterol and VLDL was considerably higher in people with psoriasis(p<0.05).Difference between psoriasis cases(6.8 ± 1.49) and control (3.08 ± 1.3) in findings of serum TGs were highly significant(p<0.001).However, difference betweenserum LDLlevelin psoriasis cases and control was not significant.Serum HDL levels in both psoriasis cases and control were unchanged .  LDL/HDL ration has not shown any significant changes in both psoriasis case and control, while in TC/HDL ratio, statistically significant difference(p<0.05) was observed. Conclusion: Patients with psoriasis have high risk of developing cardiovascular diseases. We propose that serum lipid profile screening in psoriatic patients will aid in identifying risk at an early stage. In these patients, impromptu treatment will lower the risk of cardiovascular illnesses.