Background: Acute pancreatitis (AP) is an inflammatory condition of the pancreas with a clinical course that varies from mild to severe, leading to activation of pancreatic enzyme and causing self-digestion of the pancreas. it is important to assess the disease severity in a timely and accurate manner to provide comprehensive treatment to AP patients, which will allow the clinician to consider more aggressive interventions to prevent adverse outcomes and decrease the high mortality of SAP. Methodology: The study was conducted at the Department of general surgery, Karnataka Institute of Medical Sciences, from November 2018 to December 2020. A total of 123 patients diagnosed with acute pancreatitis and undergoing treatment were included in the study. Detailed history taking, clinical examination and relevant investigations were done. Data was analyzed and entered using SPSS package. Results: Among 123 patients around 15 patients (12.2%) of the acute pancreatitis who were enrolled in to the study was found to have increased RDW. Around 2.2% patients had death who were enrolled in to the study was found to have increased RDW. Conclusion: RDW being a simple parameter which is easily available in a simple routine CBC thus, can be used as a novel predictor of acute pancreatitis.