Introduction: In the United States, 5.8 million persons suffered from mitral valve disease in 2016. Of them, 5.49 million had mitral regurgitation and 323 127 had mitral stenosis. While mitral valve disease is common in all age groups, its prevalence rises with age, affecting 5.1% of seniors 65 years of age and beyond.Of the four heart valves, the anatomy of the mitral valve is the most complicated. Additionally, it is the valve that typically results in illness. Mitral stenosis, regurgitation, and collapse of the mitral valve are the three most prevalent conditions affecting the valve. Aims: Exact cause of Mitral valve disease by Histo-pathological examination (HPE). Material and methods: The present study was a Prospective study, Prospective observational study. This Study was conducted from From Sept.2020 to Sept.2022 at Pt. visiting OPD and indoor of IPGMER and SSKM Cardiothoracic. Total 200 patients were included in this study. Result: In our study, 74 (37.0%) patients had Lt Mob Grade-2, 92 (46.0%) patients had Lt Mob Grade-3 and 34 (17.0%) patients had Lt Mob Grade-2. The value of z is 6.2431. The value of p is < .00001. The result is significant at p < .05. In our study, 3 (1.5%) patients had Lt Th Grade-1, 73 (36.5%) patients had Lt Th Grade-2, 113 (56.5%) patients had Lt Th Grade-3 and 11 (5.5%) patients had Lt Th Grade-4. The value of z is 12.1209. The value of p is < .00001. The result is significant at p < .05. In our study, 1 (0.5%) patients had Valve Calcification Grade-1, 76 (38.0%) patients had Valve Calcification Grade-2, 71 (35.5%) patients had Valve Calcification Grade-3 and 52 (26.0%) patients had Valve Calcification Grade-4. The value of z is 9.5114. The value of p is < .00001. The result is significant at p < .05. Conclusion: Understanding how to treat mitral valve problems using minimally invasive and percutaneous procedures is constantly evolving. Perhaps future research will concentrate on the long-term effects of such strategies and patient selection techniques.