European Journal of Cardiovascular Medicine

Background: To assess the effect of Magnesium sulphate on hemodynamic response and its analgesic effects in patients undergoing laparoscopic cholecystectomy. Methods: A prospective randomized single blinded study was carried out in 90 patients of ASA grade I and II, aged between 20 to 60 years weighing >50kgs scheduled for laparoscopic cholecystectomy. The patients were randomly allocated into three groups based on sealed envelope method as: Group B received Inj.Bupivacaine 0.25% 40 ml alone, Group BM received Inj.Bupivacaine 0.25% with Inj .Magnesium sulphate 15mg/kg total volume of 40ml, Group NS received Inj. Normal saline 0.9% 40ml at the conclusion of surgery.  Results: Time for first analgesic request was prolonged in Group BM (676 +/-29.55 min) when compared to Group B (406 +/- 26.6 min) and Group NS (46.67 +/- 9.32 min). Total number of tramadol doses consumed in 24hours were higher in Group NS compared to Group B and Group BM (p-value <0.001). Time duration in the ward was significantly reduced with Group BM when compared to Group NS and Group B (p-value <0.001).There were no significant haemodynamic adverse effects. Conclusions: Magnesium sulphate as an adjuvant to bupivacaine provided longer duration of analgesia when compared to bupivacaine alone and normal saline.