Background: Red cell distribution width (RDW) is an important parameter that has a critical impact on the severity of coronary artery disease, especially on that of acute myocardial infarctioni(AMI). Objective: study was to assess the correlation between red cell distribution width and left ventricular ejection fraction in patients presenting with acute myocardial infarction. Methods: Study was conducted on 110 patients admitted at tertiary care centre with acute myocardial infarction satisfying inclusion criteria. Detailed history and clinical examination was done. RDW and other CBC parameters were calculated by an automatic blood counter and measurement of LVEF done by 2D-echocardiography. Results: Out of 110 patients of acute myocardial infarction 86 were male and 24 were female. Both RDW and LVEF are linked in patients of acute myocardial infarctions, as there was statistically significant correlation between high RDW and low LVEF. Conclusions: It is observed that increase RDW and decrease LVEF were linked together which is statistically significant.